Plumbagin Prevents Secretory Diarrhea by Inhibiting CaCC and CFTR Channel Activities
نویسندگان
چکیده
منابع مشابه
Steviol Reduces MDCK Cyst Formation and Growth by Inhibiting CFTR Channel Activity and Promoting Proteasome-Mediated CFTR Degradation
Cyst enlargement in polycystic kidney disease (PKD) involves cAMP-activated proliferation of cyst-lining epithelial cells and transepithelial fluid secretion into the cyst lumen via cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. This study aimed to investigate an inhibitory effect and detailed mechanisms of steviol and its derivatives on cyst growth using a cyst mo...
متن کاملAlternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors.
Diarrhea remains the number one killer of children less than 5 years of age throughout the world. A large number of organisms are responsible including viruses (rotaviruses), bacteria (Escherichia coli and cholera vibrios) and parasites. It may not be obvious to most people but we are living during the sixth pandemic of cholera in modern memory. This pandemic started in the Celebes Islands in t...
متن کاملLysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel localized primarily at the apical or luminal surfaces of epithelial cells that line the airway, gut, and exocrine glands; it is well established that CFTR plays a pivotal role in cholera toxin (CTX)-induced secretory diarrhea. Lysophosphatidic acid (LPA), a naturally occurring phospholipid presen...
متن کاملManagement of Secretory Diarrhea
“Diarrhea is the passage of 3 or more loose or liquid stool per day, or more frequently than is normal for the individual. It is usually a symptom of gastrointestinal infection, which can be caused by a variety of bacterial, viral and parasitic organisms, infection is spread through contaminated food or drinking-water, or from person to person as a result of poor hygiene” (WHO). Diarrheal disea...
متن کاملCFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates.
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that is regulated by phosphorylation of the R domain and ATP hydrolysis at two nucleotide-binding domains (NBDs). It is controversial whether CFTR conducts ATP or whether CFTR might be closely associated with a separate ATP conductance. To characterize ATP channels associated with CFTR, we analyzed Cl- and ATP ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2019
ISSN: 1663-9812
DOI: 10.3389/fphar.2019.01181